Selected Publications

Park, S. H. & Bao, G. CRISPR/Cas9 gene editing for curing sickle cell disease. Transfus Apher Sci 60, 103060 (2021).

Hsu, P. D. et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol 31, 827–832 (2013).

Park, S. H. et al. Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease. Nucleic Acids Res 47, 7955–7972 (2019).

Bao, X. R., Pan, Y., Lee, C. M., Davis, T. H. & Bao, G. Tools for experimental and computational analyses of off-target editing by programmable nucleases. Nat Protoc 16, 10–26 (2021).

Tong, S., Moyo, B., Lee, C. M., Leong, K. & Bao, G. Engineered materials for in vivo delivery of genome-editing machinery. Nat Rev Mater 4, 726–737 (2019).

Tabor, J. J. et al. A Synthetic Genetic Edge Detection Program. Cell 137, 1272–1281 (2009).

Olson, E. J., Hartsough, L. A., Landry, B. P., Shroff, R. & Tabor, J. J. Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals. Nat Methods 11, 449–455 (2014).

Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation. Molecular Systems Biology 13, 923 (2017).

Schmidl, S. R. et al. Rewiring bacterial two-component systems by modular DNA-binding domain swapping. Nat Chem Biol 15, 690–698 (2019).

Landry, B. P., Palanki, R., Dyulgyarov, N., Hartsough, L. A. & Tabor, J. J. Phosphatase activity tunes two-component system sensor detection threshold. Nat Commun 9, 1433 (2018).

Gerhardt, K. P., Rao, S. D., Olson, E. J., Igoshin, O. A. & Tabor, J. J. Independent control of mean and noise by convolution of gene expression distributions. Nat Commun 12, 6957 (2021).

Bashor, C. J. et al. Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies. Science 364, 593–597 (2019).

Wong, B. G., Mancuso, C. P., Kiriakov, S., Bashor, C. J. & Khalil, A. S. Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER. Nat Biotechnol 36, 614–623 (2018).

O’Connell, R. W. & Bashor, C. J. The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling System for New Applications. Cell 177, 521–523 (2019).

Bashor, C. J., Helman, N. C., Yan, S. & Lim, W. A. Using Engineered Scaffold Interactions to Reshape MAP Kinase Pathway Signaling Dynamics. Science 319, 1539–1543 (2008).

Bragdon, M. D. J. et al. Cooperative assembly confers regulatory specificity and long-term genetic circuit stability. 2022.05.22.492993 (2022) doi:10.1101/2022.05.22.492993.

Keung, A. J., Bashor, C. J., Kiriakov, S., Collins, J. J. & Khalil, A. S. Using targeted chromatin regulators to engineer combinatorial and spatial transcriptional regulation. Cell 158, 110–120 (2014).

Ajo-Franklin, C. M. et al. Rational design of memory in eukaryotic cells. Genes Dev. 21, 2271–2276 (2007).

TerAvest, M. A. & Ajo-Franklin, C. M. Transforming exoelectrogens for biotechnology using synthetic biology. Biotechnology and Bioengineering 113, 687–697 (2016).

TerAvest, M. A., Zajdel, T. J. & Ajo-Franklin, C. M. The Mtr Pathway of Shewanella oneidensis MR-1 Couples Substrate Utilization to Current Production in Escherichia coli. ChemElectroChem 1, 1874–1879 (2014).

CymA and Exogenous Flavins Improve Extracellular Electron Transfer and Couple It to Cell Growth in Mtr-Expressing Escherichia coli | ACS Synthetic Biology. https://pubs.acs.org/doi/10.1021/acssynbio.5b00279.

Baruch, M., Tejedor-Sanz, S., Su, L. & Ajo-Franklin, C. M. Electronic control of redox reactions inside Escherichia coli using a genetic module. PLoS ONE 16, 1–20 (2021).

Campbell, I. J. et al. Determinants of multiheme cytochrome extracellular electron transfer uncovered by systematic peptide insertion. 2022.03.09.483668 (2022) doi:10.1101/2022.03.09.483668.

Hilton, I. B. et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol 33, 510–517 (2015).

Li, J. et al. Programmable human histone phosphorylation and gene activation using a CRISPR/Cas9-based chromatin kinase. Nat Commun 12, 896 (2021).

Bashor, C. J., Hilton, I. B., Bandukwala, H., Smith, D. M. & Veiseh, O. Engineering the next generation of cell-based therapeutics. Nat Rev Drug Discov 1–21 (2022) doi:10.1038/s41573-022-00476-6.

Reed, K. S. M. et al. Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription. 2022.05.05.490836 (2022) doi:10.1101/2022.05.05.490836.

Hilton, I. B. & Gersbach, C. A. Chemical control for CRISPR editing. Nat Chem Biol 13, 2–3 (2017).

Hilton, I. B. & Gersbach, C. A. Enabling functional genomics with genome engineering. Genome Res. 25, 1442–1455 (2015).

Mahata, B. et al. Compact engineered human transactivation modules enable potent and versatile synthetic transcriptional control. 2022.03.21.485228 (2022) doi:10.1101/2022.03.21.485228.

Yee, C. Adoptive Therapy Using Antigen-Specific T-Cell Clones. The Cancer Journal 16, 367–373 (2010).

Yee, C., Lizee, G. & Schueneman, A. J. Endogenous T-Cell Therapy: Clinical Experience. The Cancer Journal 21, 492–500 (2015).

Pan, K. et al. In Silico Defined SARS-CoV2 Epitopes May Not Predict Immunogenicity to COVID-19. 2021.07.08.451555 (2021) doi:10.1101/2021.07.08.451555.

Hasan, F., Chiu, Y., Shaw, R. M., Wang, J. & Yee, C. Hypoxia acts as an environmental cue for the human tissue-resident memory T cell differentiation program. JCI Insight 6, e138970.

Li, Y., Bleakley, M. & Yee, C. IL-21 Influences the Frequency, Phenotype, and Affinity of the Antigen-Specific CD8 T Cell Response. The Journal of Immunology 175, 2261–2269 (2005).

GDEC
Events

Rice Events